tgf β type i receptor tβri inhibitors sd208 Search Results


sd 208 (tgf β type i receptor inhibitor)  (FUJIFILM)
90
FUJIFILM sd 208 (tgf β type i receptor inhibitor)
Sd 208 (Tgf β Type I Receptor Inhibitor), supplied by FUJIFILM, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tgf+%CE%B2+type+i+receptor+t%CE%B2ri+inhibitors+sd208/aem+type+1/pmc06215881-35-0-9
Average 90 stars, based on 1 article reviews
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tgf β type i receptor tβri inhibitors sd208  (Tocris)
94
Tocris tgf β type i receptor tβri inhibitors sd208
(A) Dot plot showing Ephb2 gene expression across different hepatic cell types in mouse snRNA-seq analyzed from published dataset GSE212837. (B) Representative immunofluorescence images of human liver sections of healthy and MASH patients stained with antibodies against phosphoEphB2 (Red) and αSMA (green), DAPI counterstain for nuclei is shown in blue. (C) Messenger RNA level of EPHB2 , COL1A2 , and ACTA2 in TGF-β1 stimulated primary human HSCs at various time point (n=3). (D) Western blot showing proteins level of EphB2, aSMA, pSmad2/3 Smad2/3 and Vinculin in TGF-β1 stimulated primary human HSCs at various time point. (E) Messenger RNA level of EPHB2 upon inhibition of canonical TGF-β/SMAD with SIS3 Smad3 inhibitor, <t>SD208</t> TGFβR1 inhibitor, and SB525334 TGFβR2 inhibitor in TGF-β1-treated primary human HSCs (n=5-7). (F) Effects of silencing Smad2 and Smad3 with Mission®-esiRNA on TGF-β-induced EPHB2 mRNA expression in primary human HSCs (n=3). Non-targeting Mission®-esiRNA was used as control. (G) Accessibility peaks for the transcription factor SMAD3 on the promoter of human EPHB2 locus identified from a publicly available ChIP-seq dataset of TGF-β1 stimulated LX2 cells (GSE38103). (H) Enrichment of SMAD3 binding sites on the promoter of human EPHB2 validated by ChIP-qPCR in TGF-β1 stimulated primary human HSCs. All these data presented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 by ANOVA ns = not significant.
Tgf β Type I Receptor Tβri Inhibitors Sd208, supplied by Tocris, used in various techniques. Bioz Stars score: 94/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tgf+%CE%B2+type+i+receptor+t%CE%B2ri+inhibitors+sd208/SD+208/bio_rxiv__2025__11__19__688968-231-16-34
Average 94 stars, based on 1 article reviews
tgf β type i receptor tβri inhibitors sd208 - by Bioz Stars, 2026-11
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sd-208  (Scios Inc)
90
Scios Inc sd-208
(A) Dot plot showing Ephb2 gene expression across different hepatic cell types in mouse snRNA-seq analyzed from published dataset GSE212837. (B) Representative immunofluorescence images of human liver sections of healthy and MASH patients stained with antibodies against phosphoEphB2 (Red) and αSMA (green), DAPI counterstain for nuclei is shown in blue. (C) Messenger RNA level of EPHB2 , COL1A2 , and ACTA2 in TGF-β1 stimulated primary human HSCs at various time point (n=3). (D) Western blot showing proteins level of EphB2, aSMA, pSmad2/3 Smad2/3 and Vinculin in TGF-β1 stimulated primary human HSCs at various time point. (E) Messenger RNA level of EPHB2 upon inhibition of canonical TGF-β/SMAD with SIS3 Smad3 inhibitor, <t>SD208</t> TGFβR1 inhibitor, and SB525334 TGFβR2 inhibitor in TGF-β1-treated primary human HSCs (n=5-7). (F) Effects of silencing Smad2 and Smad3 with Mission®-esiRNA on TGF-β-induced EPHB2 mRNA expression in primary human HSCs (n=3). Non-targeting Mission®-esiRNA was used as control. (G) Accessibility peaks for the transcription factor SMAD3 on the promoter of human EPHB2 locus identified from a publicly available ChIP-seq dataset of TGF-β1 stimulated LX2 cells (GSE38103). (H) Enrichment of SMAD3 binding sites on the promoter of human EPHB2 validated by ChIP-qPCR in TGF-β1 stimulated primary human HSCs. All these data presented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 by ANOVA ns = not significant.
Sd 208, supplied by Scios Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tgf+%CE%B2+type+i+receptor+t%CE%B2ri+inhibitors+sd208/sd+208/pmc02666804-154-32-15
Average 90 stars, based on 1 article reviews
sd-208 - by Bioz Stars, 2026-11
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pe-annexinv/7aad apoptosis detection kit  (Becton Dickinson)
90
Becton Dickinson pe-annexinv/7aad apoptosis detection kit
(A) Dot plot showing Ephb2 gene expression across different hepatic cell types in mouse snRNA-seq analyzed from published dataset GSE212837. (B) Representative immunofluorescence images of human liver sections of healthy and MASH patients stained with antibodies against phosphoEphB2 (Red) and αSMA (green), DAPI counterstain for nuclei is shown in blue. (C) Messenger RNA level of EPHB2 , COL1A2 , and ACTA2 in TGF-β1 stimulated primary human HSCs at various time point (n=3). (D) Western blot showing proteins level of EphB2, aSMA, pSmad2/3 Smad2/3 and Vinculin in TGF-β1 stimulated primary human HSCs at various time point. (E) Messenger RNA level of EPHB2 upon inhibition of canonical TGF-β/SMAD with SIS3 Smad3 inhibitor, <t>SD208</t> TGFβR1 inhibitor, and SB525334 TGFβR2 inhibitor in TGF-β1-treated primary human HSCs (n=5-7). (F) Effects of silencing Smad2 and Smad3 with Mission®-esiRNA on TGF-β-induced EPHB2 mRNA expression in primary human HSCs (n=3). Non-targeting Mission®-esiRNA was used as control. (G) Accessibility peaks for the transcription factor SMAD3 on the promoter of human EPHB2 locus identified from a publicly available ChIP-seq dataset of TGF-β1 stimulated LX2 cells (GSE38103). (H) Enrichment of SMAD3 binding sites on the promoter of human EPHB2 validated by ChIP-qPCR in TGF-β1 stimulated primary human HSCs. All these data presented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 by ANOVA ns = not significant.
Pe Annexinv/7aad Apoptosis Detection Kit, supplied by Becton Dickinson, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tgf+%CE%B2+type+i+receptor+t%CE%B2ri+inhibitors+sd208/7+aad/pm37894453-54-5-9
Average 90 stars, based on 1 article reviews
pe-annexinv/7aad apoptosis detection kit - by Bioz Stars, 2026-11
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tgf β type i receptor inhibitor sd208  (Selleck Chemicals)
93
Selleck Chemicals tgf β type i receptor inhibitor sd208
(A) Dot plot showing Ephb2 gene expression across different hepatic cell types in mouse snRNA-seq analyzed from published dataset GSE212837. (B) Representative immunofluorescence images of human liver sections of healthy and MASH patients stained with antibodies against phosphoEphB2 (Red) and αSMA (green), DAPI counterstain for nuclei is shown in blue. (C) Messenger RNA level of EPHB2 , COL1A2 , and ACTA2 in TGF-β1 stimulated primary human HSCs at various time point (n=3). (D) Western blot showing proteins level of EphB2, aSMA, pSmad2/3 Smad2/3 and Vinculin in TGF-β1 stimulated primary human HSCs at various time point. (E) Messenger RNA level of EPHB2 upon inhibition of canonical TGF-β/SMAD with SIS3 Smad3 inhibitor, <t>SD208</t> TGFβR1 inhibitor, and SB525334 TGFβR2 inhibitor in TGF-β1-treated primary human HSCs (n=5-7). (F) Effects of silencing Smad2 and Smad3 with Mission®-esiRNA on TGF-β-induced EPHB2 mRNA expression in primary human HSCs (n=3). Non-targeting Mission®-esiRNA was used as control. (G) Accessibility peaks for the transcription factor SMAD3 on the promoter of human EPHB2 locus identified from a publicly available ChIP-seq dataset of TGF-β1 stimulated LX2 cells (GSE38103). (H) Enrichment of SMAD3 binding sites on the promoter of human EPHB2 validated by ChIP-qPCR in TGF-β1 stimulated primary human HSCs. All these data presented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 by ANOVA ns = not significant.
Tgf β Type I Receptor Inhibitor Sd208, supplied by Selleck Chemicals, used in various techniques. Bioz Stars score: 93/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/tgf+%CE%B2+type+i+receptor+t%CE%B2ri+inhibitors+sd208/SD-208/pm30336139-70-36-44
Average 93 stars, based on 1 article reviews
tgf β type i receptor inhibitor sd208 - by Bioz Stars, 2026-11
93/100 stars
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Image Search Results


(A) Dot plot showing Ephb2 gene expression across different hepatic cell types in mouse snRNA-seq analyzed from published dataset GSE212837. (B) Representative immunofluorescence images of human liver sections of healthy and MASH patients stained with antibodies against phosphoEphB2 (Red) and αSMA (green), DAPI counterstain for nuclei is shown in blue. (C) Messenger RNA level of EPHB2 , COL1A2 , and ACTA2 in TGF-β1 stimulated primary human HSCs at various time point (n=3). (D) Western blot showing proteins level of EphB2, aSMA, pSmad2/3 Smad2/3 and Vinculin in TGF-β1 stimulated primary human HSCs at various time point. (E) Messenger RNA level of EPHB2 upon inhibition of canonical TGF-β/SMAD with SIS3 Smad3 inhibitor, SD208 TGFβR1 inhibitor, and SB525334 TGFβR2 inhibitor in TGF-β1-treated primary human HSCs (n=5-7). (F) Effects of silencing Smad2 and Smad3 with Mission®-esiRNA on TGF-β-induced EPHB2 mRNA expression in primary human HSCs (n=3). Non-targeting Mission®-esiRNA was used as control. (G) Accessibility peaks for the transcription factor SMAD3 on the promoter of human EPHB2 locus identified from a publicly available ChIP-seq dataset of TGF-β1 stimulated LX2 cells (GSE38103). (H) Enrichment of SMAD3 binding sites on the promoter of human EPHB2 validated by ChIP-qPCR in TGF-β1 stimulated primary human HSCs. All these data presented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 by ANOVA ns = not significant.

Journal: bioRxiv

Article Title: EPHB2 promotes diet-induced MASH liver fibrosis

doi: 10.1101/2025.11.19.688968

Figure Lengend Snippet: (A) Dot plot showing Ephb2 gene expression across different hepatic cell types in mouse snRNA-seq analyzed from published dataset GSE212837. (B) Representative immunofluorescence images of human liver sections of healthy and MASH patients stained with antibodies against phosphoEphB2 (Red) and αSMA (green), DAPI counterstain for nuclei is shown in blue. (C) Messenger RNA level of EPHB2 , COL1A2 , and ACTA2 in TGF-β1 stimulated primary human HSCs at various time point (n=3). (D) Western blot showing proteins level of EphB2, aSMA, pSmad2/3 Smad2/3 and Vinculin in TGF-β1 stimulated primary human HSCs at various time point. (E) Messenger RNA level of EPHB2 upon inhibition of canonical TGF-β/SMAD with SIS3 Smad3 inhibitor, SD208 TGFβR1 inhibitor, and SB525334 TGFβR2 inhibitor in TGF-β1-treated primary human HSCs (n=5-7). (F) Effects of silencing Smad2 and Smad3 with Mission®-esiRNA on TGF-β-induced EPHB2 mRNA expression in primary human HSCs (n=3). Non-targeting Mission®-esiRNA was used as control. (G) Accessibility peaks for the transcription factor SMAD3 on the promoter of human EPHB2 locus identified from a publicly available ChIP-seq dataset of TGF-β1 stimulated LX2 cells (GSE38103). (H) Enrichment of SMAD3 binding sites on the promoter of human EPHB2 validated by ChIP-qPCR in TGF-β1 stimulated primary human HSCs. All these data presented as mean ± SEM, * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 by ANOVA ns = not significant.

Article Snippet: To assess the effect of TGF-β/SMAD canonical pathway on EphB2 expression, HSCs were incubated with the TGF-β type I receptor (TβRI) inhibitors SD208 (1μM), SB525334 (200nM), and the SMAD3 inhibitor SIS3 (5μM) (all from Tocris) for 4h before stimulation with recombinant human TGF-β1 (10ng/ml) for 48h.

Techniques: Gene Expression, Immunofluorescence, Staining, Western Blot, Inhibition, esiRNA, Expressing, Control, ChIP-sequencing, Binding Assay, ChIP-qPCR